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KIDNEY BIOPSY RESULTS December 18, 2006

Posted by wmmbb in Life Experience.
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I went to see my specialist today and got a copy of the laboratory results from my renal biopsy. Admittedly the medical language takes a moment to begin to decode. It is, for example, commonly known, that “itis” means inflammation, and then it is just a matter of constructing meaning from the common words.

Medicine is not without its political implications, of which the most important is what is available to least advantaged member of society. I do not quite fit the bill, but I solely a public patient, since I do not have medical insurance of any kind, and thus far I have not experienced this as a significant disadvantage. I suppose that, up to this point, I do have the minimum financial resources available to me to meet the upfront expenses of consultations with doctors and undertake some tests, such as ultra sound radiography.

My understanding is, and I must be very explicit I am in no way an expert in this area, that renal biopsies, perhaps thirty years ago could end badly. Now it seems with the combination of a renal doctor and a radiologist, they are if not completely accurate, considerably safer. I would almost have no hesitation in having further kidney biopsies done, other than all medical procedures are a freakout for me, including taking blood of which I have had much experience. To my mind a kidney biopsy is decidedly lower on the scale of concern than bone marrow biopsies, of which I have had two. In these procedures the human interaction skills of the practitioners become, at least for me, critically important.

As far as I can tell there are two types of diagnosis of the kidney samples. I may be wrong but I think they have applied varies petrie dish tests that they have looked at using an ordinary light microscope and then they have used the election microscopy to look with greater resolution at the samples. The conclusion was:

The overall diagnosis is not completely certain, but most of the features would favour a primary mesanglocapillary glomerulonephritis (? type 1.) but with relatively weak IF findings. No Light Microscopic or EM features to suggest secondary glomerulonephritis related to fibril deposition etc. No evidence of amyloid.

The result is uncertain but there are indications that it is a primary condition that means, I am told there is no guaranteed medication, but one possible approach is to use a steroid, which may or may not work, and has sometimes nasty side effects. So I was not keen to jump at this solution, but it is probably the only way to go.

As for the medical words they lose their mystery when deconstructed. “Mesa” I am guessing refers to mesial, which means “towards the middle”. “Angi” means vessel carrying lymph or blood. Capillary is self explanatory. The kidneys as I understand it, filters the blood at two levels the nephorn and the glomuli, which appear to be inflamed.

PLEASE NOTE: I am relating my experience, not suggesting I have any knowledge, and thus my inferences and other opinions may prove incorrect. If true, I will endeavour to provide a more accurate account at a later time.

UPDATE:

The first trial of medication has not worked, instead my kidney condition has deterioated. Now I am on prednisone.

FURTHER UPDATE: 06 December 2009

Now I am on prednisone and have severe and persistent <a href="Now the blood-soaked man of peace, Obama, has morphed with his magic words the Taliban into the existential enemy of United States and its subordinate allies, much like the Durand Line, national boundaries become irrelevant. David E Sanger and Eric Schmitt report in The New York Times:

The Obama administration is turning up the pressure on Pakistan to fight the Taliban inside its borders, warning that if it does not act more aggressively the United States will use considerably more force on the Pakistani side of the border to shut down Taliban attacks on American forces in Afghanistan, American and Pakistani officials said. The blunt message was delivered in a tense encounter in Pakistan last month, before President Obama announced his new war strategy, when Gen. James L. Jones, Mr. Obama’s national security adviser, and John O. Brennan, the White House counterterrorism chief, met with the heads of Pakistan’s military and its intelligence service. United States officials said the message did not amount to an ultimatum, but rather it was intended to prod a reluctant Pakistani military to go after Taliban insurgents in Pakistan who are directing attacks in Afghanistan. For their part the Pakistanis interpreted the message as a fairly bald warning that unless Pakistan moved quickly to act against two Taliban groups they have so far refused to attack, the United States was prepared to take unilateral action to expand Predator drone attacks beyond the tribal areas and, if needed, to resume raids by Special Operations forces into the country against Al Qaeda and Taliban leaders. A senior administration official, asked about the encounter, declined to go into details but added quickly, “I think they read our intentions accurately.” A Pakistani official who has been briefed on the meetings said, “Jones’s message was if that Pakistani help wasn’t forthcoming, the United States would have to do it themselves.”

There was a time when a war was launched against Saddam Hussien and Iraq by the very same alliance led by the United States for invading another country, or alleged country, Kuwait on a the basis of a breach of International Law. Such breeches of proper international behavior had been overlooked when Iraq had engaged in savagery against Iran. The significant points about this part of the report is the preparedness on behalf of the US Government to “take unilateral action to expand Predator drone attacks beyond the Tribal Areas” presumably to protect the Occupation Military and other forces in Afghanistan. What can be done to stop this violence? What must be done? And thereby to save the lives of the poor and suffering Afghanis and Pakistani human beings for which geo-strategic and resource theft judged in terms of win/lose have no significance whatsoever.”>swelling in my legs and feet.

Dr Erich Rosenberger writes on Chronic Kidney Disease and its causes. I found it informative.

Comments»

1. Kathy Clearwater - January 26, 2009

Hi! Having been a renal patient, on dialysis and had a kidney transplant, I can tell you of a few good websites to garner some information on your condition. Your report says basically, you have inflammation of the glomeruli, but they don’t know why.

http://www.kidney.org/

http://kidney.niddk.nih.gov/index.htm

http://www.unos.org/

Hope this helps! Good luck with everything.

2. wmmbb - January 26, 2009

Thank you very much Kathy.

I should find out more about my condition.

3. KIDNEY DISEASE AND PREDNISONE « DUCKPOND - August 26, 2009

[...] DISEASE AND PREDNISONE August 26, 2009 Posted by wmmbb in Life Experience. trackback My kidney disease, gromerulonephritis (MPGN Type I), has progressively since December 2006 become worse. I am not [...]

4. Shelley - January 19, 2011

Hi I too have been diagnosised with this disease :( I was healthy 38yr old until one day I had noticed swelling in my ankles (other then my thyroid being removed when I was 7 years old, I had a goiter). Since it’s been a while since your initial posting, I would like to hear how your doing now. And did the prednisone ever end up working for you?! I am currently taking 60mg a day. This entire disease is just crazy, seems some test results get better..then 5 more go bad :o Very frusterating for myself and my husband!! ugh!! Any updates you can share would be greatly appreciated :) Hope my email finds you to be completely cured of this disease =)

Shelley

wmmbb - January 20, 2011

Hi Shelley,

Thanks for the comment. I am not cured as yet and have moved from prednisone to cyclophosphamide, which I began in October. After awhile it became clear that prednisone was not working. According to my renal doctor is takes about three months to confirm whether the new treatment works. I am still getting, like you, variable results. My specialist is on the view that these treatments are hit and miss. They work well for some, but not for all.

I hope despite the variability of the results that prednisone will work for you. Nice to hear from you and all the best.

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